Article

NELFA-mediated promoter-proximal pausing restrains YAP-driven transcription and shapes context-dependent outcomes in breast cancer

2025-12-29

Abstract excerpt

Overexpression of YAP is associated with tumor progression in multiple malignancies. YAP is the key transcriptional effector of Hippo signaling: a conserved pathway from Drosophila (Yki) to humans (YAP). In a Drosophila screen, we identified NELFA, a core component of the promoter-proximal pausing (PPP) complex, as a suppressor of Yki-driven hyperproliferation. We investigated whether PPP–YAP regulatory interact...

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Literature Corpus work: 2f2d99ac-5790-509a-84e0-0c9e76f7c90e
DOI: 10.64898/2025.12.29.696819

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