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Article

The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression.

Developmental cell - 28 May 2013

Koontz Laura M, Liu-Chittenden Yi, Yin Feng, Zheng Yonggang, Yu Jianzhong, Huang Bo, Chen Qian, Wu Shian, Pan Duojia

Abstract excerpt

The Hippo tumor suppressor pathway restricts tissue growth by inactivating the transcriptional coactivator Yki. Although Sd has been implicated as a DNA-binding transcription factor partner for Yki and can genetically account for gain-of-function Yki phenotypes, how Yki regulates normal tissue gr...

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Identifiers

PMID: 23725764
DOI: 10.1016/j.devcel.2013.04.021
PMCID: PMC3705890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23725764-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Research trail→

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The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression.PMID 23725764Read ↗

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.Semantic proximity Read ↗

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ SizeSemantic proximity Read ↗

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.Semantic proximity Read ↗

Pits and CtBP control tissue growth in <i>Drosophila melanogaster</i> with the Hippo pathway transcription repressor, TgiSemantic proximity Read ↗

Elucidation of a universal size-control mechanism in Drosophila and mammals.Semantic proximity Read ↗

A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie.Semantic proximity Read ↗

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in <i>Drosophila</i>Semantic proximity Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

The bantam microRNA is a target of the hippo tumor-suppressor pathway.Semantic proximity Read ↗

The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression.Semantic proximity Read ↗

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