Back to search

Article

An autoregulatory switch in sex-specific <i>phf7</i> transcription causes loss of sexual identity and tumors in the <i>Drosophila</i> female germline

2020-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Maintenance of germ cell sexual identity is essential for reproduction. Entry into the spermatogenesis or oogenesis pathway requires that the appropriate gene network is activated and the antagonist network is silenced. For example, in Drosophila female germ cells, forced expression of the testis-specific PHD finger protein 7 (PHF7) disrupts oogenesis leading to either an agametic or germ cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
66a6f85b-a8db-5ec9-8797-a7168284803d
DOI
10.1101/2020.05.13.093344
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
An autoregulatory switch in sex-specific <i>phf7</i> transcription causes loss of sexual identity and tumors in the <i>Drosophila</i> female germlineDOI 10.1101/2020.05.13.093344
Phf7 controls male sex determination in the Drosophila germline.Semantic proximity
<i>tudor-domain containing protein 5-prime</i> promotes male sexual identity in the <i>Drosophila</i> germline and is repressed in females by <i>Sex lethal</i>Semantic proximity
A germline PAF1 paralog complex ensures cell type-specific gene expressionSemantic proximity
Chromosome-specific maturation of the epigenome in the Drosophila male germlineSemantic proximity
Germline Sex Determination regulates sex-specific signaling between germline stem cells and their nicheSemantic proximity
RDC complex executes a dynamic piRNA program during <i>Drosophila</i> spermatogenesis to safeguard male fertilitySemantic proximity
Decoding the regulatory logic of the <i>Drosophila</i> male stem cell systemSemantic proximity
Trajectory Mapping of the Early <i>Drosophila</i> Germline Reveals Controls of Zygotic Activation and Sex DifferentiationSemantic proximity
The <i>Drosophila</i> histone methyl-transferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiationSemantic proximity
In the <i>Drosophila</i> germline H2Av and Arp6 suppress transposons by driving piRNA pathway expressionSemantic proximity
Single-cell transcriptomic profiling of <i>bam</i> mutant tumor reveals germline heterogeneity and <i>gcrf1</i> as a modulator in <i>Drosophila</i> germ cellsSemantic proximity
Human Germ Cell Specification via Combinatorial Expression of Prioritized Transcription FactorsSemantic proximity
Select a neighboring publication to make it the new centre.