Article
p53 and RB Cooperate to Suppress Transposable Elements
2023-02-06
Abstract excerpt
Accumulating data suggest that the long interspersed nuclear element 1 (LINE1), a major class of transposable elements, can promote tumorigenesis by causing deletions of tumor suppressor genes, amplifications of oncogenes, and chromosomal translocations(1). LINE1 and other transposable elements such as short interspersed nuclear elements (SINEs) can be activated during cancer development. Aberrant transposon expre...
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Identifiers and source
- Literature Corpus work
- 7a35aafe-5ed0-58b3-b7ea-7bb1ec89a555
- DOI
- 10.1101/2023.02.06.527304