Article

Identification of Novel Regulators of LINE-1 Expression via CRISPR/Cas9 Screening

2025-06-04

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Long Interspersed Nuclear Elements-1 (LINE-1, L1) are transposable elements that make up roughly 17% of the human genome. These elements can copy and insert themselves into new genomic locations [1]. Typically, LINE-1 is repressed in healthy tissues but may become activated in various human diseases. LINE-1 expression has been associated with aging [2–4], neur...

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Literature Corpus work: feb72687-11ec-5d30-ab9b-2d70610a84a4
DOI: 10.21203/rs.3.rs-6726282/v1

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