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Article

p53 in the game of transposons.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Nov 2016

Wylie Annika, Jones Amanda E, Abrams John M

Abstract excerpt

Throughout the animal kingdom, p53 genes function to restrain mobile elements and recent observations indicate that transposons become derepressed in human cancers. Together, these emerging lines of evidence suggest that cancers driven by p53 mutations could represent "transpospoathies," i.e. disease states linked to eruptions of mobile elements. The transposopathy hypothesis predicts that p53 acts through...

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Identifiers

PMID: 27644006
DOI: 10.1002/bies.201600115
PMCID: PMC5142446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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