Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 genes function to restrain mobile elements.

Genes & development - 1 Jan 2016

Wylie Annika, Jones Amanda E, D'Brot Alejandro, Lu Wan-Jin, Kurtz Paula, Moran John V, Rakheja Dinesh, Chen Kenneth S, Hammer Robert E, Comerford Sarah A, Amatruda James F, Abrams John M

Abstract excerpt

Throughout the animal kingdom, p53 genes govern stress response networks by specifying adaptive transcriptional responses. The human member of this gene family is mutated in most cancers, but precisely how p53 functions to mediate tumor suppression is not well understood. Using Drosophila and zebrafish models, we show that p53 restricts retrotransposon activity and genetically interacts with components of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Zebrafish
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genetic Variation

Share to Neoplasms

Share to Retroelements

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 26701264
DOI: 10.1101/gad.266098.115
PMCID: PMC4701979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 genes function to restrain mobile elements.PMID 26701264Read ↗

p53 in the game of transposons.Semantic proximity Read ↗

p53 and RB Cooperate to Suppress Transposable ElementsSemantic proximity Read ↗

p53-mediated regulation of LINE1 retrotransposon-derived R-loopsSemantic proximity Read ↗

Our Conflict with Transposable Elements and Its Implications for Human Disease.Semantic proximity Read ↗

p53 mediated regulation of LINE1 retrotransposition derived R-loopsSemantic proximity Read ↗

Retrotransposon Activity in Chronic Lymphocytic Leukemia: Associations with RNA Splicing and <i>TP53</i> DysfunctionSemantic proximity Read ↗

p53 is required for female germline stem cell maintenance in P-element hybrid dysgenesis.Semantic proximity Read ↗

Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damageSemantic proximity Read ↗

p53 is required for female germline stem cell maintenance in <i>P</i> -element hybrid dysgenesisSemantic proximity Read ↗

Jump around: transposons in and out of the laboratorySemantic proximity Read ↗

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.Semantic proximity Read ↗

Charting the regulatory landscape of TP53 on transposable elements in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.