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Article

p53-mediated regulation of LINE1 retrotransposon-derived R-loops

17 Jan 2025

Abstract excerpt

Long interspersed nuclear element 1 (LINE1/L1) retrotransposons, which comprise 17% of the human genome, typically remain inactive in healthy somatic cells but are reactivated in several cancers. We previously demonstrated that p53 silences L1 transposons in human somatic cells, potentially acting as a tumor-suppressive mechanism. However, the precise molecular mechanisms underlying p53-mediated repression of L1...

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PMID: 39828096
DOI: 10.1016/j.jbc.2025.108200

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