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LINE-1 transposon derepression and epigenetic remodeling in Retinoblastoma

2026-07-27

Abstract excerpt

Retinoblastoma (RB), the most common pediatric intraocular malignancy, is initiated by biallelic inactivation of the RB1 tumor suppressor gene. Although LINE-1 (L1) retrotransposon activation has been linked to genomic instability and tumor evolution in several adult cancers, its contribution to pediatric malignancies remains poorly understood. Here, we investigated L1 expression in retinoblastoma samples from an...

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Literature Corpus work
9d5e0bd7-6378-5734-9dfb-9102290fcc2e
DOI
10.64898/2026.07.25.740688
Open publication

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LINE-1 transposon derepression and epigenetic remodeling in RetinoblastomaDOI 10.64898/2026.07.25.740688
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