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Article

Mice deficient for a small cluster of Piwi-interacting RNAs implicate Piwi-interacting RNAs in transposon control.

Biology of reproduction - 1 Jul 2008

Xu Mingang, You Yun, Hunsicker Patricia, Hori Tamaki, Small Chris, Griswold Michael D, Hecht Norman B

Abstract excerpt

The mammalian testis expresses a class of small noncoding RNAs that interact with mammalian PIWI proteins. In mice, the PIWI-interacting RNAs (piRNAs) partner with mammalian PIWI proteins, PIWIL1 and PIWIL2, also known as MIWI and MILI, to maintain transposon silencing in the germline genome. Her...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18401007
DOI: 10.1095/biolreprod.108.068072

Genes

PIWIL1
PIWIL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18401007-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice deficient for a small cluster of Piwi-interacting RNAs implicate Piwi-interacting RNAs in transposon control.PMID 18401007Read ↗

MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.Semantic proximity Read ↗

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.Semantic proximity Read ↗

Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines.Semantic proximity Read ↗

Zili is required for germ cell differentiation and meiosis in zebrafish.Semantic proximity Read ↗

Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertilitySemantic proximity Read ↗

Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes.Semantic proximity Read ↗

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.Semantic proximity Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.Semantic proximity Read ↗

Developmentally regulated piRNA clusters implicate MILI in transposon control.Semantic proximity Read ↗

PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development.Semantic proximity Read ↗

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.Semantic proximity Read ↗

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