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Article

p53-dependent down-regulation of telomerase is mediated by p21waf1.

The Journal of biological chemistry - 3 Dec 2004

Shats Igor, Milyavsky Michael, Tang Xiaohu, Stambolsky Perry, Erez Neta, Brosh Ran, Kogan Ira, Braunstein Ilana, Tzukerman Maty, Ginsberg Doron, Rotter Varda

Abstract excerpt

Inactivation of p53 and activation of telomerase occur in the majority of human cancers, raising the possibility of a link between these two pathways. Overexpression of wild-type p53 down-regulates the enzymatic activity of telomerase in various cancer cell lines through transcriptional repression of its catalytic subunit, human telomerase reverse transcriptase (hTERT). In this study, we re-evaluated the role of...

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PMID: 15371422
DOI: 10.1074/jbc.M402502200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p53-dependent down-regulation of telomerase is mediated by p21waf1.PMID 15371422Read ↗

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Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.Semantic proximity Read ↗

C-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (hTERT) promoter.Semantic proximity Read ↗

E2F-1 represses transcription of the human telomerase reverse transcriptase gene.Semantic proximity Read ↗

hTERT promotes cell adhesion and migration independent of telomerase activity.Semantic proximity Read ↗

Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanismsSemantic proximity Read ↗

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