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Article

p53 mediated regulation of LINE1 retrotransposition derived R-loops

2024-04-15

Abstract excerpt

Long Interspersed Nuclear Element 1 (LINE1/L1) retrotransposons, comprising around 17% of the human genome, typically remain quiescent in healthy somatic cells but become activated in various cancer types. Our recent investigation reveals that p53 silences L1 transposons in human somatic cells, potentially constituting a tumor suppressive pathway. In this study, we demonstrate that p53 silences both L1mRNA-gDNA (c...

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Identifiers and source

Literature Corpus work
fc163972-b136-528e-9a6b-3f947a0cf9b4
DOI
10.1101/2024.04.12.589154
Open publication

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p53 mediated regulation of LINE1 retrotransposition derived R-loopsDOI 10.1101/2024.04.12.589154
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