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Article

An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences.

Molecular cell - 15 Dec 2016

Ishak Charles A, Marshall Aren E, Passos Daniel T, White Carlee R, Kim Seung J, Cecchini Matthew J, Ferwati Sara, MacDonald William A, Howlett Christopher J, Welch Ian D, Rubin Seth M, Mann Mellissa R W, Dick Frederick A

Abstract excerpt

Repetitive genomic regions include tandem sequence repeats and interspersed repeats, such as endogenous retroviruses and LINE-1 elements. Repressive heterochromatin domains silence expression of these sequences through mechanisms that remain poorly understood. Here, we present evidence that the retinoblastoma protein (pRB) utilizes a cell-cycle-independent interaction with E2F1 to recruit enhancer of zeste...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27889452
DOI: 10.1016/j.molcel.2016.10.021
PMCID: PMC5340194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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