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Retrotransposon Activity in Chronic Lymphocytic Leukemia: Associations with RNA Splicing and <i>TP53</i> Dysfunction

2026-07-17

Abstract excerpt

Retroelements (RE), particularly autonomous Long Interspersed Element-1 (LINE-1), function as potent drivers of genomic instability in various malignancies. While normally silenced by epigenetic mechanisms, their reactivation in cancer cells can drive tumor evolution. TP53 is known to repress LINE-1 transcription; however, the consequences of TP53 dysfunction on retrotransposition and transcriptional activity in...

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Literature Corpus work
896439f5-dccb-54e7-a60d-bd2519cbcf41
DOI
10.64898/2026.07.16.738931
Open publication

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Retrotransposon Activity in Chronic Lymphocytic Leukemia: Associations with RNA Splicing and <i>TP53</i> DysfunctionDOI 10.64898/2026.07.16.738931
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