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The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

2020-06-19

Abstract excerpt

<h4>ABSTRACT</h4> Nearly half of the human genome is made of transposable elements (TEs) whose activity continues to impact its structure and function. Among them, Long INterspersed Element class 1 (LINE-1 or L1) elements are the only autonomously active TEs in humans. L1s are expressed and mobilized in different cancers, generating mutagenic insertions that could affect malignancy. Tumor suppressor microRNAs are...

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Identifiers and source

Literature Corpus work
c75fa3c7-d40e-58fa-bb6f-cd5210d09259
DOI
10.1101/2020.06.18.158667
Open publication

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The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotranspositionDOI 10.1101/2020.06.18.158667
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