Article

Proteolytic activation of fatty acid synthase signals pan-stress resolution

2023-09-28

Abstract excerpt

Chronic stress and inflammation are not only outcomes of pathological states but rather major drivers of many human diseases 1-4 . Ideally, a given stress program is downregulated to basal levels upon restoration of homeostasis. Chronic responsiveness despite stress mitigation suggests a failure to sense the resolution of the initiating stressor. Here we show that a proteolytic cleavage event of fatty acid syntha...

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Literature Corpus work: 7a10910d-ede7-539e-ba0c-5bedab0ab15c
DOI: 10.1101/2023.09.27.559743

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