Article

Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice

2023-03-15

Abstract excerpt

Cell death frequently occurs in the pathogenesis of obesity and non-alcoholic fatty liver disease (NAFLD). However, the exact contribution of core cell death machinery to disease manifestations remains ill-defined. Here, we show via the direct comparison of mice genetically deficient in apoptotic caspase-8 in myeloid cells, or the essential necroptotic regulators, Receptor-interacting protein kinase-3 (RIPK3) and...

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Literature Corpus work: 1d3ce357-5897-5263-8082-9d451e69f7aa
DOI: 10.1101/2023.03.14.532682

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