Article

Mig6 decreases hepatic EGFR activation and survival during saturated fatty acid-induced endoplasmic reticulum stress

2020-11-25

Abstract excerpt

<h4>ABSTRACT</h4> Hyperlipidemia associated with obesity and type 2 diabetes (T2D) promotes excess hepatic lipid storage (steatosis) and endoplasmic reticulum (ER) stress, thereby reducing hepatic cell proliferation and survival. An important receptor tyrosine kinase controlling liver proliferation and survival is the epidermal growth factor receptor (EGFR). EGFR expression and activation are decreased during ste...

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Literature Corpus work: f15a6a8c-7ec6-5e53-a283-4ce836c932b9
DOI: 10.1101/2020.11.24.380527

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