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Article

Lipidomic and Proteomic Alterations Induced by Even and Odd Medium-Chain Fatty Acids on Fibroblasts of Long-Chain Fatty Acid Oxidation Disorders.

International journal of molecular sciences - 29 Sept 2021

Alatibi Khaled I, Tholen Stefan, Wehbe Zeinab, Hagenbuchner Judith, Karall Daniela, Ausserlechner Michael J, Schilling Oliver, Grünert Sarah C, Vockley Jerry, Tucci Sara

Abstract excerpt

Medium-chain fatty acids (mc-FAs) are currently applied in the treatment of long-chain fatty acid oxidation disorders (lc-FAOD) characterized by impaired β-oxidation. Here, we performed lipidomic and proteomic analysis in fibroblasts from patients with very long-chain acyl-CoA dehydrogenase (VLCADD) and long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHADD) deficiencies after incubation with heptanoate (C7) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34638902
DOI: 10.3390/ijms221910556
PMCID: PMC8508682

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