Article

Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

2023-03-20

Abstract excerpt

<title>Abstract</title> <p> Metabolic diseases are closely linked to aberrant synthesis of endogenous fatty acids in the liver, called <italic>de novo</italic> lipogenesis (DNL), which is mediated by the enzyme fatty acid synthase (FASN). The composition of complex lipids consists of saturated or monosaturated fatty acids, which can be endogenously produced, and polyunsaturated fatty acids (PUFA), which are st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 738a14f1-f3d4-536a-9b58-45cea6b2b3e5
DOI: 10.21203/rs.3.rs-1008467/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fatty acid synthesis suppresses dietary polyunsaturated fatty acid useDOI 10.21203/rs.3.rs-1008467/v3Read

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitisSemantic proximity Read

Regulation of odd chain fatty acid metabolism in the development of metabolic diseases in mice fed a low protein dietSemantic proximity Read

Systematic mapping of genetic interactions for <i>de novo</i> fatty acid synthesisSemantic proximity Read

Hepatic ketogenesis regulates lipid homeostasis via ACSL1-mediated fatty acid partitioningSemantic proximity Read

Dietary omega-3 polyunsaturated fatty acids relate to lower liver lipids and adipose-tissue insulin resistance, modulated by fatty acid desaturase 1 rs174546 in type 2 diabetes.Semantic proximity Read

Maternal palmitic acid overload establishes a SETD1A-dependent epigenetic memory that programs offspring susceptibility to metabolic liver diseaseSemantic proximity Read

Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH PathogenesisSemantic proximity Read

ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axisSemantic proximity Read

Histone Succinylation-Driven LINE-1 Reactivation Links High-Fat Diet Stress to Hepatic Inflammation and Liver DiseaseSemantic proximity Read

Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availabilitySemantic proximity Read

Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice.Semantic proximity Read

Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.Semantic proximity Read