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Article

Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism

1 Nov 2022

Abstract excerpt

Cold affects many aspects of biology, medicine, agriculture, and industry. Here, we identify a conserved endoplasmic reticulum (ER) stress response, distinct from the canonical unfolded protein response, that maintains lipid homeostasis during extreme cold. We establish that the ER stress sensor IRE-1 is critical for resistance to extreme cold and activated by cold temperature. Specifically, neuronal IRE-1...

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PMID: 36450261
DOI: 10.1016/j.celrep.2022.111739

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