Article
Long-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21.
Biochimica et biophysica acta. Molecular basis of disease - 1 Jan 2022
Dille Matthias, Nikolic Aleksandra, Wahlers Natalie, Fahlbusch Pia, Jacob Sylvia, Hartwig Sonja, Lehr Stefan, Kabra Dhiraj, Klymenko Oleksiy, Al-Hasani Hadi, Kotzka Jörg, Knebel Birgit
Abstract excerpt
Chronic stress leads to post-traumatic stress disorder (PTSD) and metabolic disorders including fatty liver. We hypothesized that stress-induced molecular mechanisms alter energy metabolism, thereby promoting hepatic lipid accumulation even after a stress-free recovery period. In this context, we investigated fibroblast growth factor-21 (FGF21) as protective for energy and glucose homeostasis. FGF21 knockout mice...
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