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Article

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.

Nature reviews. Cancer - 1 Oct 2007

Menendez Javier A, Lupu Ruth

Abstract excerpt

There is a renewed interest in the ultimate role of fatty acid synthase (FASN)--a key lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids--in cancer pathogenesis. Tumour-associated FASN, by conferring growth and survival advantages rather than functioning as an anabolic energy-storage pathway, appears to necessarily accompany the natural history of most human cancers. A recent...

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Source

Identifiers

PMID: 17882277
DOI: 10.1038/nrc2222

Genes

FASN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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