Article
Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2022
Zheng Xiaofeng, Ho Qing Wei Calvin, Chua Minni, Stelmashenko Olga, Yeo Xin Yi, Muralidharan Sneha, Torta Federico, Chew Elaine Guo Yan, Lian Michelle Mulan, Foo Jia Nee, Jung Sangyong, Wong Sunny Hei, Tan Nguan Soon, Tong Nanwei, Rutter Guy A, Wenk Markus R, Silver David L, Berggren Per-Olof, Ali Yusuf
Abstract excerpt
SignificanceWith obesity on the rise, there is a growing appreciation for intracellular lipid droplet (LD) regulation. Here, we show how saturated fatty acids (SFAs) reduce fat storage-inducing transmembrane protein 2 (FIT2)-facilitated, pancreatic β cell LD biogenesis, which in turn induces β cell dysfunction and death, leading to diabetes. This mechanism involves direct acylation of FIT2 cysteine residues,...
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