Article

Inflammatory stress signaling via NF- <i>k</i> B alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells

2022-05-05

Abstract excerpt

There is a growing appreciation that a tight relationship exists between cholesterol homeostasis and immunity in leukocytes, however, this relationship has not been deeply explored in the vascular endothelium. Endothelial cells (ECs) rapidly respond to extrinsic signals, such as tissue damage or microbial infection, by upregulating factors to activate and recruit circulating leukocytes to the site of injury and ab...

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Literature Corpus work: 6adcfe73-b42d-5aa7-8fee-ffac8c370908
DOI: 10.1101/2022.05.05.490737

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