Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using ASMase knockout mice to model human diseases.

Handbook of experimental pharmacology - 1 Jan 2013

Hua Guoqiang, Kolesnick Richard

Abstract excerpt

Acid sphingomyelinase (ASMase) is a key initiator of sphingomyelin/ceramide signal transduction activated by many stress stimuli. Over the past two decades, much progress has been made in defining the clinical relevance of sphingomyelin/ceramide signaling in numerous diseases using ASMase knockout mice. Organs that operate this pathway are numerous and the disease states regulated are diverse, with ceramide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ceramides
Share to Disease Models, Animal
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Signal Transduction

Share to Species Specificity

Share to Sphingomyelin Phosphodiesterase

Share to Sphingomyelins

Source

Open in PubMed Open full text

Identifiers

PMID: 23563650
DOI: 10.1007/978-3-7091-1511-4_2
PMCID: PMC7121422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using ASMase knockout mice to model human diseases.PMID 23563650Read ↗

Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.Semantic proximity Read ↗

Cardiovascular Dysfunction and Altered Lysosomal Signaling in a Murine Model of Acid Sphingomyelinase DeficiencySemantic proximity Read ↗

Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids.Semantic proximity Read ↗

Pathological study of mice with total deficiency of sphingolipid activator proteins (SAP knockout mice).Semantic proximity Read ↗

Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiologySemantic proximity Read ↗

Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease.Semantic proximity Read ↗

Sphingolipids as cell fate regulators in lung development and diseaseSemantic proximity Read ↗

Physiology and pathophysiology of sphingolipid metabolism and signalingSemantic proximity Read ↗

Analysis of the lung pathology and alveolar macrophage function in the acid sphingomyelinase--deficient mouse model of Niemann-Pick disease.Semantic proximity Read ↗

Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration.Semantic proximity Read ↗

Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.Semantic proximity Read ↗

Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-β-synthase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.