Article

Activated fatty acid synthesis pathway in macrophages propagates pathogenic fibroblast expansion after myocardial infarction

2025-10-13

Abstract excerpt

Metabolic pathways, such as fatty acid oxidation and oxidative phosphorylation, can modulate inflammatory cells. However, little is known about the effects of the fatty acid synthesis pathway in macrophages on inflammation and cardiac remodeling after myocardial infarction (MI). Using spatial metabolomics, here we show that cardiac macrophages residing in the infarct synthesize de novo fatty acids and increase th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c9c59650-5a5a-5af4-95ab-b9c4389e6dea
DOI: 10.1101/2025.10.10.681697

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activated fatty acid synthesis pathway in macrophages propagates pathogenic fibroblast expansion after myocardial infarctionDOI 10.1101/2025.10.10.681697Read

Interpretable machine learning coupled to spatial transcriptomics unveils mechanisms of macrophage-driven fibroblast activation in ischemic cardiomyopathySemantic proximity Read

Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarctionSemantic proximity Read

Transcriptome Data Analysis of Primary Cardiomyopathies Reveals Perturbations in Arachidonic Acid MetabolismSemantic proximity Read

Unveiling macrophage diversity in myocardial ischemia-reperfusion injury: identification of a distinct lipid-associated macrophage subsetSemantic proximity Read

Spatial multi-omic map of human myocardial infarctionSemantic proximity Read

Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic DysfunctionSemantic proximity Read

SF3A2 deacetylation at lysin 10 mitigates myocardial pathological remodeling by reprogramming cardiomyocyte metabolismSemantic proximity Read

ACLY Promotes Cardiac Fibrosis via the Regulation of DNL and Histone AcetylationSemantic proximity Read

METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs.Semantic proximity Read

ACE-inhibition induces a cardioprotective transcriptional response in the metabolic syndrome heartSemantic proximity Read

Combined analysis of bulk, single-cell RNA sequencing, and spatial transcriptomics reveals the expression patterns of lipid metabolism and ferroptosis in the immune microenvironment of metabolic-associated fatty liver diseaseSemantic proximity Read

Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory ResponsesSemantic proximity Read