Article

Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s disease

2019-08-12

Abstract excerpt

<h4>Summary</h4> The linear cause-consequence relationship linking amyloid-β peptide (Aβ) accumulation to neuronal dysfunction in Alzheimer disease (AD) is gradually replaced by the concept that Aβ initiates complex inflammatory-like cellular alterations that progressively become Aβ independent and lead to brain dyshomeostasis. Little is known about the pathophysiology of this cellular phase of AD. We use here tw...

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Literature Corpus work: 54bef23f-f9cc-5d12-b47a-f2da6d97117f
DOI: 10.1101/719930

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