Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons.

doi:10.1016/j.stem.2024.03.013

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Article

Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons.

Cell stem cell - 2 May 2024

Al-Dalahmah Osama, Lam Matti, McInvale Julie J, Qu Wenhui, Nguyen Trang, Mun Jeong-Yeon, Kwon Sam, Ifediora Nkechime, Mahajan Aayushi, Humala Nelson, Winters Tristan, Angeles Ellen, Jakubiak Kelly A, Kühn Rebekka, Kim Yoon A, De Rosa Maria Caterina, Doege Claudia A, Paryani Fahad, Flowers Xena, Dovas Athanassios, Mela Angeliki, Lu Hong, DeTure Michael A, Vonsattel Jean Paul, Wszolek Zbigniew K, Dickson Dennis W, Kuhlmann Tanja, Zaehres Holm, Schöler Hans R, Sproul Andrew A, Siegelin Markus D, De Jager Philip L, Goldman James E, Menon Vilas, Canoll Peter, Hargus Gunnar

Abstract excerpt

Frontotemporal dementia (FTD) is an incurable group of early-onset dementias that can be caused by the deposition of hyperphosphorylated tau in patient brains. However, the mechanisms leading to neurodegeneration remain largely unknown. Here, we combined single-cell analyses of FTD patient brains with a stem cell culture and transplantation model of FTD. We identified disease phenotypes in FTD neurons carrying...

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PMID: 38626772
DOI: 10.1016/j.stem.2024.03.013
PMCID: PMC11373574

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MAPT

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