Article

Amyloid-beta increases MBP and MOBP translation in oligodendrocytes through dysregulation of hnRNP A2 dependent RNA dynamics

2024-04-19

Abstract excerpt

Oligodendrocyte dysfunction, myelin degeneration, and white matter structural alterations are critical events in Alzheimer's disease (AD) that contribute to cognitive decline. A key hallmark of AD, Abeta oligomers, disrupt oligodendrocyte and myelin homeostasis, but a comprehensive global analysis of the mechanisms involved is lacking. Here, transcriptomic profiling of Abeta-exposed oligodendrocytes revealed wides...

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Literature Corpus work: 4f79aaca-966e-5bce-b0da-fabfae645441
DOI: 10.1101/2024.04.19.590214

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Amyloid-beta increases MBP and MOBP translation in oligodendrocytes through dysregulation of hnRNP A2 dependent RNA dynamicsDOI 10.1101/2024.04.19.590214Read

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