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Article

TET1 attenuates human pluripotency-related heterogeneities and enhances differentiation capabilities

2022-04-30

Abstract excerpt

Human induced pluripotent stem cells (hiPSCs) offer transformative potential for developmental research and therapeutic discovery; however, their variable characteristics are a significant barrier to their broader application. We reprogrammed hiPSCs by adding TET1, a DNA-demethylating dioxygenase, to produce TET1-iPSCs (T-iPSCs) with enhanced epithelialization and differentiation capabilities. A default differenti...

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Literature Corpus work
30173d3c-2101-5d04-9238-6a9d42689a99
DOI
10.1101/2022.04.29.489839
Open publication

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TET1 attenuates human pluripotency-related heterogeneities and enhances differentiation capabilitiesDOI 10.1101/2022.04.29.489839
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