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DOT1L inhibitor improves early development of porcine somatic cell nuclear transfer embryos

20 Jun 2017

Abstract excerpt

Incomplete epigenetic reprogramming of the genome of donor cells causes poor early and full-term developmental efficiency of somatic cell nuclear transfer (SCNT) embryos. Previous research indicate that inhibition of the histone H3 K79 methyltransferase DOT1L, using a selective pharmacological inhibitor EPZ004777 (EPZ), significantly improved reprogramming efficiency during the generation of mouse induced...

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PMID: 28632762
DOI: 10.1371/journal.pone.0179436

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