Article

Defining reprogramming checkpoints from single-cell analysis of induced pluripotency

2019-01-26

Abstract excerpt

Elucidating the mechanism of reprogramming is confounded by heterogeneity due to the low efficiency and differential kinetics of obtaining induced pluripotent stem cells (iPSCs) from somatic cells. Therefore, we increased the efficiency with a novel combination of epigenetic and signaling molecules and profiled the transcriptomes of individual reprogramming cells. Contrary to the established temporal order, somati...

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Literature Corpus work: f9f0ffa2-4139-5c66-ba43-4fc22ce5a060
DOI: 10.1101/531244

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