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Article

Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.

Nature cell biology - 1 May 2018

Finley Lydia W S, Vardhana Santosha A, Carey Bryce W, Alonso-Curbelo Direna, Koche Richard, Chen Yanyang, Wen Duancheng, King Bryan, Radler Megan R, Rafii Shahin, Lowe Scott W, Allis C David, Thompson Craig B

Abstract excerpt

A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but the relative contribution of Brd4 to pluripotency remains unclear. Here, we show that Brd4 is dispensable for self-renewal and pluripotency of embryonic stem cells (ESCs). When maintained in their ground...

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Identifiers

PMID: 29662175
DOI: 10.1038/s41556-018-0086-3
PMCID: PMC5937285

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.PMID 29662175Read ↗

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