Article

Epigenetic resetting of human pluripotency

2017-06-06

Abstract excerpt

<h4>SUMMARY</h4> Much attention has focussed on conversion of human pluripotent stem cells (PSC) to a more naive developmental status. Here we provide a method for resetting via transient histone deacetylase inhibition. The protocol is effective across multiple PSC lines and can proceed without karyotype change. Reset cells can be expanded without feeders with a doubling time of around 24 hours. WNT inhibition st...

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Literature Corpus work: f17c55cf-bcf6-5ffc-ab03-f38d30d8b683
DOI: 10.1101/146712

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