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Article

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity.

Science advances - 20 Feb 2026

Sahoo Satyaranjan, Nagraj Tarun, Bhattacharya Debanjali, Nagar Nupur, Somyajit Kumar, Poluri Krishna Mohan, Nagaraju Ganesh

Abstract excerpt

Fanconi anemia (FA) is characterized by bone marrow failure, congenital abnormalities, and cancer predisposition. Mutations in RAD51 paralogs have been identified in FA-like disorders and cancers. Although the role of RAD51 paralogs is well established in homologous recombination (HR)-mediated DNA repair, little is known about their role during replication stress responses. Here, we report that the RAD51C-XRCC3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41719405
DOI: 10.1126/sciadv.aea5932
PMCID: PMC12922753

Genes

FANCM
RAD51
RAD51C
XRCC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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