Article

RAD18 opposes transcription-associated genome instability through FANCD2 recruitment

2022-06-25

Abstract excerpt

DNA replication is a vulnerable time for genome stability maintenance. Intrinsic stressors, as well as oncogenic stress, can challenge replication by fostering conflicts with transcription and stabilizing DNA:RNA hybrids. RAD18 is an E3 ubiquitin ligase for PCNA that is involved in coordinating DNA damage tolerance pathways to preserve genome stability during replication. In this study, we show that RAD18 deficien...

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Literature Corpus work: a5c1d762-55bc-5d7f-a27b-319be9e86fe8
DOI: 10.1101/2022.06.24.497439

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