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Article

R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.

Genes & development - 15 Jan 2012

Stirling Peter C, Chan Yujia A, Minaker Sean W, Aristizabal Maria J, Barrett Irene, Sipahimalani Payal, Kobor Michael S, Hieter Philip

Abstract excerpt

Genome instability via RNA:DNA hybrid-mediated R loops has been observed in mutants involved in various aspects of transcription and RNA processing. The prevalence of this mechanism among essential chromosome instability (CIN) genes remains unclear. In a secondary screen for increased Rad52 foci in CIN mutants, representing ∼25% of essential genes, we identified seven essential subunits of the mRNA cleavage and...

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Identifiers

PMID: 22279048
DOI: 10.1101/gad.179721.111
PMCID: PMC3273840

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