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Article

An essential gene screening identifies yeast Mot1 as a suppressor of R-loops and genome instability.

PLoS genetics - 1 Feb 2026

Soler-Oliva María E, Domínguez-Sierra Rocío A, Gaillard Hélène, Aguilera Andrés

Abstract excerpt

Transcription is essential for cellular function, but it can also lead to genetic instability, particularly through the formation of secondary structures such as R-loops, which consist of an RNA-DNA hybrid and a displaced DNA strand. Unscheduled R-loop accumulation is a major source of DNA damage and has been associated with several human diseases, including cancer. While multiple factors involved in RNA...

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Identifiers

PMID: 41662397
DOI: 10.1371/journal.pgen.1012040
PMCID: PMC12912698

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