Article
RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability.
Nature communications - 5 Sept 2024
Jalan Manisha, Sharma Aman, Pei Xin, Weinhold Nils, Buechelmaier Erika S, Zhu Yingjie, Ahmed-Seghir Sana, Ratnakumar Abhirami, Di Bona Melody, McDermott Niamh, Gomez-Aguilar Joan, Anderson Kyrie S, Ng Charlotte K Y, Selenica Pier, Bakhoum Samuel F, Reis-Filho Jorge S, Riaz Nadeem, Powell Simon N
Abstract excerpt
Collisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability. These collisions occur in part due to the formation of RNA-DNA hybrids termed R-loops, in which a newly transcribed RNA molecule hybridizes with the DNA template strand. This study investigated the role of RAD52, a known DNA repair factor, in preventing collisions by directing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.