Article

SMARCAD1 Regulates R-Loops at Active Replication Forks Linked to Cancer Mutation Hotspots

2024-09-15

Abstract excerpt

<h4>ABSTRACT</h4> DNA replication often encounters obstacles like the stalled transcription machinery and R-loops. While ribonucleases and DNA-RNA helicases can resolve these structures, the role of chromatin remodelers remains understudied. Through a series of in vitro and in vivo experiments, we show that the chromatin remodeler SMARCAD1, which associates with active replication forks, is crucial for resolvin...

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Literature Corpus work: 4f3c98fe-be39-5322-ad3e-a3c056559c93
DOI: 10.1101/2024.09.13.612941

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