DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing

Abstract excerpt

R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability. Increased R-loops cause replication stress and chromosome fragility and have been associated with diseases such as neurodegeneration and cancer. Although excessive R-loops are a feature of cells that are defective in RNA processing, what causes them to form is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to RNA and protein synthesis mechanisms
• Share to RNA Research and Splicing
• Share to Viral Infections and Immunology Research