Article

Checkpoint defects require WRNIP1 to counteract R-loop-associated genomic instability

2019-11-29

Abstract excerpt

<h4>ABSTRACT</h4> Conflicts between replication and transcription are common source of genome instability and many factors participate in prevention or removal of harmful R-loops. Here, we demonstrate that a WRNIP1-mediated response plays an important role in counteracting accumulation of aberrant R-loops. Using human cellular models with compromised ATR-dependent checkpoint activation, we show that WRNIP1 is sta...

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Literature Corpus work: c71e960f-4d4c-559f-899a-46efbadc1a99
DOI: 10.1101/858761

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