Article

Clinical validation of a statin-benefit polygenic score using real-world cohorts of primary prevention participants

2025-10-13

Abstract excerpt

<h4>Background</h4> Polygenic risk scores derived from coronary artery disease genome-wide association studies are associated with statin relative risk reduction. <h4>Objective</h4> Examine the relationship between coronary artery disease polygenic risk scores that include variants below thresholds of genome-wide significance and statin primary prevention of major adverse cardiovascular events. <h4>Methods</h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77561666-a9e2-585c-ab4a-e484c9adf0b2
DOI: 10.1101/2025.10.09.25337698

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clinical validation of a statin-benefit polygenic score using real-world cohorts of primary prevention participantsDOI 10.1101/2025.10.09.25337698Read

Polygenic risk score and statin relative risk reduction for primary prevention in a real-world populationSemantic proximity Read

Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.Semantic proximity Read

Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.Semantic proximity Read

European and US Guideline-Based Statin Eligibility, Genetically Predicted Coronary Artery Disease, and the Risk of Major Coronary Events.Semantic proximity Read

Broad Clinical Manifestations of Polygenic Risk for Coronary Artery Disease in the Women’s Health InitiativeSemantic proximity Read

Taking the next steps to implement polygenic risk scoring for improved risk stratification and primary prevention of coronary artery disease.Semantic proximity Read

Effect of disclosing a polygenic risk score for coronary heart disease on adverse cardiovascular events: 10-year follow-up of the MI-GENES randomized clinical trialSemantic proximity Read

Clinical utility of polygenic risk scores for coronary artery disease.Semantic proximity Read

Using polygenic risk scores for prioritising individuals at greatest need of a CVD risk assessmentSemantic proximity Read

A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study.Semantic proximity Read

Development and Validation of a Polygenic Risk Score for Stroke in the Chinese Population.Semantic proximity Read

Polygenic Risk Scores to Identify CVD Risk and Tailor Therapy: Hope or Hype?Semantic proximity Read