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Development and Validation of a Polygenic Risk Score for Stroke in the Chinese Population.

Neurology - 10 Aug 2021

Lu Xiangfeng, Niu Xiaoge, Shen Chong, Liu Fangchao, Liu Zhongying, Huang Keyong, Wang Laiyuan, Li Jianxin, Hu Dongsheng, Zhao Yingxin, Yang Xueli, Lu Fanghong, Liu Xiaoqing, Cao Jie, Chen Shufeng, Li Hongfan, Tang Wuzhuang, Ren Zhanyun, Yu Ling, Wu Xianping, Wu Xigui, Li Ying, Zhang Huan, Huang Jianfeng, Hu Zhibin, Shen Hongbing, Willer Cristen J, Gu Dongfeng

Abstract excerpt

OBJECTIVE: To construct a polygenic risk score (PRS) for stroke and evaluate its utility in risk stratification and primary prevention for stroke. METHODS: Using a meta-analytic approach and large genome-wide association results for stroke and stroke-related traits in East Asians, we generated a combined PRS (metaPRS) by incorporating 534 genetic variants in a training set of 2,872 patients with stroke and 2,494...

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Identifiers

PMID: 34031205
DOI: 10.1212/WNL.0000000000012263
PMCID: PMC8424497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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