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Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.

Journal of the American College of Cardiology - 9 Jun 2020

Aragam Krishna G, Dobbyn Amanda, Judy Renae, Chaffin Mark, Chaudhary Kumardeep, Hindy George, Cagan Andrew, Finneran Phoebe, Weng Lu-Chen, Loos Ruth J F, Nadkarni Girish, Cho Judy H, Kember Rachel L, Baras Aris, Reid Jeffrey, Overton John, Philippakis Anthony, Ellinor Patrick T, Weiss Scott T, Rader Daniel J, Lubitz Steven A, Smoller Jordan W, Karlson Elizabeth W, Khera Amit V, Kathiresan Sekar, Do Ron, Damrauer Scott M, Natarajan Pradeep

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS) for coronary artery disease (CAD) identify high-risk individuals more likely to benefit from primary prevention statin therapy. Whether polygenic CAD risk is captured by conventional paradigms for assessing clinical cardiovascular risk remains unclear. OBJECTIVES: This study sought to intersect polygenic risk with guideline-based recommendations and management patterns for...

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PMID: 32498804
DOI: 10.1016/j.jacc.2020.04.027
PMCID: PMC7346975

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