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Article

Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.

JAMA - 18 Feb 2020

Mosley Jonathan D, Gupta Deepak K, Tan Jingyi, Yao Jie, Wells Quinn S, Shaffer Christian M, Kundu Suman, Robinson-Cohen Cassianne, Psaty Bruce M, Rich Stephen S, Post Wendy S, Guo Xiuqing, Rotter Jerome I, Roden Dan M, Gerszten Robert E, Wang Thomas J

Abstract excerpt

Importance: Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs) could be useful for population-wide coronary heart disease (CHD) screening. Objective: To determine whether a polygenic risk score improves prediction of CHD compared with a guideline-recommended clinical risk equation. Design, Setting, and Participants: A retrospective cohort study of the predictive accuracy of a...

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Identifiers

PMID: 32068817
DOI: 10.1001/jama.2019.21782
PMCID: PMC7042849

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