Article

Broad Clinical Manifestations of Polygenic Risk for Coronary Artery Disease in the Women’s Health Initiative

2021-06-18

Abstract excerpt

<h4>Background</h4> The genetic basis for coronary artery disease (CAD) risk is highly complex. Genome-wide polygenic risk scores (PRS) can help to quantify that risk, but the broader impacts of polygenic risk for CAD are not well characterized. <h4>Methods</h4> We measured polygenic risk for CAD using the metaGRS, a previously validated genome-wide PRS, in a subset of genotyped participants from the Women’s Healt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 04a1acec-ecb5-5e60-9838-23823e19bd1d
DOI: 10.1101/2021.06.15.21258993

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Broad Clinical Manifestations of Polygenic Risk for Coronary Artery Disease in the Women’s Health InitiativeDOI 10.1101/2021.06.15.21258993Read

Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.Semantic proximity Read

A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.Semantic proximity Read

Polygenic Risk Scores to Identify CVD Risk and Tailor Therapy: Hope or Hype?Semantic proximity Read

Polygenic risk scores in coronary artery disease.Semantic proximity Read

Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular Risk Collaboration, and the European Association of Preventive CardiologySemantic proximity Read

Polygenic background modifies penetrance of monogenic variants conferring risk for coronary artery disease, breast cancer, or colorectal cancerSemantic proximity Read

A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study.Semantic proximity Read

Taking the next steps to implement polygenic risk scoring for improved risk stratification and primary prevention of coronary artery disease.Semantic proximity Read

Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary preventionSemantic proximity Read

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary diseaseSemantic proximity Read

Clinical utility of polygenic risk scores for coronary artery disease.Semantic proximity Read

Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.Semantic proximity Read