Article

A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

2020-08-29

Abstract excerpt

<h4>SUMMARY</h4> FOXA pioneer transcription factors (TFs) displace nucleosomes and prime chromatin across enhancers of different endodermal organs in multipotent precursors before lineage induction. Here, we examined patterns and mechanisms of FOXA target site engagement using human pluripotent stem cell models of endodermal organ development. Unexpectedly, we find that only a subset of pancreatic, hepatic, and a...

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Literature Corpus work: 758a1136-b85e-5235-8dda-ca782039660c
DOI: 10.1101/2020.08.28.263020

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