Article

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency

2025-10-03

Abstract excerpt

<h4>ABSTRACT</h4> In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associated H3K27me3 histone modifications. In contrast, poised enhancers (PEs) are scarce in naive hPSCs that model pre-implantation epiblast. PEs form abundant chromosomal contacts with developmental genes,...

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Literature Corpus work: 710f6027-f040-5231-80f7-adc8a6f55230
DOI: 10.1101/2025.10.02.679816

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